Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

Mengyang Zhang; Junqing He; Youbin Zheng; Guoyue Shi; Min Zhang

doi:10.1039/D2AN01393B

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Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring†

Mengyang Zhang,‡^a Junqing He,‡^a Youbin Zheng,^b Guoyue Shi

^a and Min Zhang

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, Shanghai 200241, China
E-mail: mzhang@chem.ecnu.edu.cn

^b Department of Chemical Engineering, Technion – Israel Institute of Technology, Haifa 320003, Israel

Abstract

Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

This article is part of the themed collection: Analyst HOT Articles 2022

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Article information

DOI: https://doi.org/10.1039/D2AN01393B
Article type: Communication
Submitted: 23 Авг. 2022
Accepted: 13 Сент. 2022
First published: 13 Сент. 2022

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Analyst, 2022,147, 4413-4416

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Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

M. Zhang, J. He, Y. Zheng, G. Shi and M. Zhang, Analyst, 2022, 147, 4413 DOI: 10.1039/D2AN01393B

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Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring†

Abstract

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Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

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