Guilherme Dal Poggetto, Adam DiCaprio, Mikhail Reibarkh and Ryan D. Cohen
Analyst, 2024,149, 2227-2231
DOI:
10.1039/D3AN02150E,
Communication
Pure shift NMR experiments greatly enhance spectral resolution by collapsing multiplet structures into singlets and, with water suppression, can be used for aqueous samples. Here, we combine ultra-clean pure-shift NMR (SAPPHIRE) with two different internally encoded water suppression schemes to achieve optimal performance for small molecule and macrocyclic peptide pharmaceuticals in water and acetonitrile–water mixtures.
