Decarboxylative Chlorination of α, β-Unsaturated Acids

Abstract

Herein, an unprecedented oxidative decarboxylative chlorination of α,β-unsaturated acids for α-chloroketones is reported. This green and sustainable approach employs Fe(III)-catalyzed LMCT to generate chloride radical from non-hazardous LiCl under violet light irradiation. Molecular oxygen serves as the oxygen source for the ketone group, while naturally abundant unsaturated acids replace unstable alkenes or alkynes, enabling an efficient and eco-friendly synthesis of α-phenacyl chlorides.