Issue 78, 2024

Secondary structure changes as the potential H2 sensing mechanism of group D [FeFe]-hydrogenases

Abstract

[FeFe]-hydrogenases function as both H2 catalysts and sensors. While catalysis is well investigated, details regarding the H2 sensing mechanism are limited. Here, we relate protein structure changes to H2 sensing, similar to light-driven bio-sensors. Our results highlight how identical cofactors incorporated in alternative protein scaffolds serve different functions in nature.

Graphical abstract: Secondary structure changes as the potential H2 sensing mechanism of group D [FeFe]-hydrogenases

Supplementary files

Article information

Article type
Communication
Submitted
25 jun 2024
Accepted
04 sep 2024
First published
05 sep 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 10914-10917

Secondary structure changes as the potential H2 sensing mechanism of group D [FeFe]-hydrogenases

I. Voloshyn, C. Schumann, P. R. Cabotaje, A. Zamader, H. Land and M. Senger, Chem. Commun., 2024, 60, 10914 DOI: 10.1039/D4CC03098B

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