From the journal:

Chemical Communications

Host-Guest Recognition-Mediated Reversible and Orthogonal Regulation of DNAzyme Activity

lin xiao,   Haitao Zhu,   Yanmei Gao  and  Liang Xu  

Abstract

The host-guest recognition system is incorporated into the core region of the 10-23 DNAzyme for precise regulation of its functionality. Biochemical experiments demonstrate reversible and orthogonal control of the DNAzyme function using cucurbit(7)uril and its competitive guests. Furthermore, cellular experiments indicate the gene expression can be effectively manipulated through this ligand-controllable DNAzyme.

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Article information

DOI
https://doi.org/10.1039/D4CC05330C
Article type
Communication
Submitted
09 okt 2024
Accepted
30 dec 2024
First published
02 jan 2025

Chem. Commun., 2025, Accepted Manuscript

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Host-Guest Recognition-Mediated Reversible and Orthogonal Regulation of DNAzyme Activity

L. xiao, H. Zhu, Y. Gao and L. Xu, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D4CC05330C

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