From the journal:

Chemical Communications

Properties of the major Zn2+-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier

Jin Lu,   Stephen J. Hierons,   Swati Arya,   Remi Fritzen,   Sirilata Polepalli,   Siavash Khazaipoul,   Alan J. Stewart  and  Claudia Andrea Blindauer  

Abstract

The foetal plasma protein α-fetoprotein (AFP) harbours a high-affinity zinc binding site that is likely involved in transport and delivery of essential zinc during foetal development. Based on a recent electron microscopy structure of AFP and aided by biophysical studies on an AFP-derived peptide, we present a refined 5-coordinate model for this site.

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D4CC06611A
Article type
Communication
Accepted
25 dec 2024
First published
27 dec 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Accepted Manuscript

Permissions

Request permissions

Properties of the major Zn2+-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier

J. Lu, S. J. Hierons, S. Arya, R. Fritzen, S. Polepalli, S. Khazaipoul, A. J. Stewart and C. A. Blindauer, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D4CC06611A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements