Recent advances in catalytic asymmetric condensation reactions for the synthesis of nitrogen containing compounds

Abstract

Asymmetric synthesis of functionalized nitrogen-containing compounds has been a hot topic. The condensation of amines with carbonyl compounds presents one of the most efficient methods for the synthesis of nitrogen-containing compounds, such as imines, enamines and α-amino ketones, which have applications in many fields. This review summarizes the most significant concepts and advances in this field, focusing on desymmetrization or dynamic kinetic resolution, the de novo cycloaromatization and the Heyns rearrangement. Additionally, we expect our review to inspire the design of related structures or condensation reactions.