Recent advances in the application of calcium(ii) triflimide in organic synthesis

Abstract

Calcium(II) triflimide, which is known for its environmentally friendly characteristics, has emerged as a sustainable substitute for transition metal catalysts, rare-earth metals, and strong Brønsted acids in promoting organic synthesis. This advancement has attracted substantial attention from the scientific community. Recently, sophisticated methodologies incorporating calcium(II) triflimide have been devised, such as cyclizations, dehydrative functionalizations, hydroarylation reactions, hydrofunctionalizations, reductions, rearrangements, and novel selenylations. These have been applied to a wide variety of substrates, including alcohols, alkenes, alkynes, carbonyl compounds, imines, N,O-acetals, and selenides, for the formation of C–C or C–X bonds. The objective of this review is to offer a thorough and meticulous overview of the recent progress in the utilization of calcium(II) triflimide as a catalyst in organic synthesis, summarizing the significant achievements in reaction methodologies and the probable reaction mechanisms.