Recent Advances in Catalytic Asymmetric Reactions of Morita–Baylis–Hillman adducts

Abstract

Morita-Baylis-Hillman adducts has become an efficient synthon for the construction of C-C or C-heteroatom bonds, and has been widely used in the asymmetric synthesis of various new optically pure compounds. The use of Morita-Baylis-Hillman acetates in asymmetric catalytic reactions has exploded since the pioneering work of Kim and co-workers. In this review, the remarkable progress of Morita-Baylis-Hillman adducts in the asymmetric construction of chiral compounds from 2012 are summarized and discussed based on the different reaction types.