Progress in Catalytic Enantioselective Construction of Difluoroalkylated Stereogenic Center

Abstract

Molecules bearing the difluoroalkyl groups were very important in pharmaceuticals, argrochemicals and materials. In recent years, more and more attentions were paid to develop novel synthetic method for constructing compounds including CF2R groups. In particular, the construction of difluoralkyl stereogenic center is thriving. This review focused on catalytic asymmetric difluoroalkylation to construction of difluoralkyl stereogenic center which summarized the synthetic methods, the active intermediate involved and asymmetric strategies applied. The product diversity, selectivity and proposed mechanism were highlighted and at the same time, the outlook and existing challenges were provided.