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Precise control of antimicrobial delivery can prevent the adverse effects of antibiotics. By exploiting the photothermal activity of polydopamine nanoparticles along with the distinct transition temperatures of liposomes, a near-infrared (NIR) laser can be used to control the sequential delivery of an antibiotic and its adjuvant from a nanocomposite hydrogel—preventing bacterial growth.

Graphical abstract: Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels

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