Issue 52, 2015

Metal-free domino one-pot protocols for quinoline synthesis

Abstract

Quinoline is one of the most widely investigated scaffolds by synthetic chemists because of its medicinal importance. A wide range of metal-catalyzed, metal-free, multi-step or domino one-pot protocols are reported in the literature for construction of this scaffold. Several reviews have appeared on synthetic aspects of this scaffold, however there is no focused review on metal-free domino one-pot protocols. Domino one-pot protocols offer an opportunity to access highly functionalized final products from simple starting materials. Because of this unique feature of domino protocols, in recent years their utility for generation of molecular libraries has been widely appreciated. In this review, all contributions till March 2015 are surveyed with particular emphasis on metal-free domino reactions for quinoline ring construction and are discussed herein along with mechanistic aspects.

Graphical abstract: Metal-free domino one-pot protocols for quinoline synthesis

Article information

Article type
Review Article
Submitted
09 Mac 2015
Accepted
29 Apr 2015
First published
30 Apr 2015

RSC Adv., 2015,5, 42020-42053

Metal-free domino one-pot protocols for quinoline synthesis

J. B. Bharate, R. A. Vishwakarma and S. B. Bharate, RSC Adv., 2015, 5, 42020 DOI: 10.1039/C5RA07798B

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