Issue 33, 2019

Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans

Abstract

Enantioselective synthesis of chiral isochromans bearing a terminal alkyne moiety has been accomplished by copper-catalysed enantioselective intramolecular propargylic substitution reactions of propargylic esters with alcoholic nucleophiles. This method represents the first successful example which directly introduced a terminal alkyne group into chiral isochromans.

Graphical abstract: Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans

Supplementary files

Article information

Article type
Paper
Submitted
23 Mei 2019
Accepted
10 Jun 2019
First published
17 Jun 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 18918-18922

Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans

S. Liu, K. Nakajima and Y. Nishibayashi, RSC Adv., 2019, 9, 18918 DOI: 10.1039/C9RA03880A

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