Changlin Yao, Lei Wang, Xinyuan Wang and Xutang Tao
CrystEngComm, 2021,23, 2928-2932
DOI:
10.1039/D1CE00237F,
Communication
The transformation of the piroxicam monohydrate to form I or form II could be achieved precisely by adjusting the particle size itself in a 99% acetone-1% H2O solvent at 31 °C. Mechanistic studies have demonstrated that the particle size could affect both the maximum concentration of piroxicam and the heterogeneous nucleation of form II during the solution-mediated phase transformation (SMPT) process, finally determining the polymorph outcome.
