Srinivas Samala, Do Hyun Ryu, Choong Eui Song and Eun Jeong Yoo
Org. Biomol. Chem., 2019,17, 1773-1777
DOI:
10.1039/C8OB02463D,
Communication
An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using N-aromatic zwitterions, aldehydes, and amino acids. The developed reactions proceed through azomethine ylides generated in situ from the decarboxylated reactions of aldehydes and amino acids followed by the [3 + 2] cycloaddition of N-aromatic zwitterions under mild reaction conditions.
