Perspective
The international society for clinical spectroscopy; reflections on the first 10 years
The article provides a perspective overview of the development and current status of the field of biomedical spectroscopy, on the occasion of the tenth anniversary of the foundation of the International Society for Clinical Spectroscopy (CLIRSPEC).
FTIR characterisation of chondroitin sulfate E (CS-E) di-, tetra-, and hexasaccharide derivatives and their biotinylated or reducing conjugates
FTIR spectroscopy explores molecular information of chondroitin sulfate E di-, tetra-, and hexasaccharide derivatives and their biotinylated or reducing conjugates.
Raman spectroscopy in tandem with machine learning – based decision logic methods for characterization and detection of primary precancerous and cancerous cells
The main steps of the current research: (a) treatment and cell growth; (b) preparing the samples for measurements; (c) acquiring the Raman spectra; (d) pre-processing of the spectra and feature extraction; (e) analyzing the data and decision system.
Paper
Ex vivo spectroscopic characterisation of the biological activity of pancreatic cyst fluid
Pancreatic cystic lesions (PCLs) are fluid-filled sacs often identified incidentally during abdominal imaging for unrelated pancreatic indications.
Paper
PyFasma: an open-source, modular Python package for preprocessing and multivariate analysis of Raman spectroscopy data
A free and open-source Python package for processing and analysing Raman spectra.
FTIR-based machine learning for prediction of malignant transformation in oral epithelial dysplasia
The FTIR-based machine learning approach outperforms traditional histopathology in predicting malignant transformation risk in Oral Epithelial Dysplasia, potentially offering a quantitative and objective tool for clinical diagnosis.
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Insights into the cellular lipid cascade of prostate cells explored using infrared microspectroscopy
Arachidonic acid uptake across invasive and non-invasive prostate cancer cell lines is tracked using infrared microspectroscopy, showing key differences in uptake between the cell types, highlighting differences in metabolomic processes.
Paper
Full fingerprint hyperspectral imaging of prostate cancer tissue microarrays within clinical timeframes using quantum cascade laser microscopy
A QCL microscope is compared to a state-of-the-art FTIR system and is found to capture prostate tissue data twenty times faster, with greater signal to noise, and improved tissue classification, paving the way for clinical adoption.
Paper
Extracellular vesicles derived from ovarian cancer cell lines discriminated by biochemical and Fourier transform infrared spectroscopy approaches
Biochemical and FTIR approaches to discriminate ovarian cancer cell-derived EVs.
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Raman spectroscopy of ovarian and peritoneal tissue in the assessment of ovarian cancer
We demonstrate that Raman spectroscopy is a viable tool for ovarian cancer assessment.
Tissue analysis by vibrational spectroscopy in Hirschsprung disease: feasibility and potential as a new intraoperative tool
Hirschprung disease is treated by surgical removing the non-functional part of colon. The delineation of this part is difficult but vibrational spectroscopy emerges as a potential candidate to help in it.
Effects of supplementation of macular pigment carotenoids on ocular health: a Raman spectroscopic study of human blood serum of glaucoma patients
Supplementing glaucoma patients with macular pigment carotenoids improved ocular health, as confirmed by Serum Raman spectroscopy correlating with MPOD and ocular parameters. This highlights vast potential benefits of the method for healthcare.
About this collection
This collection of articles highlights work from the 13th conference in the SPEC series, held in Ioannia, Greece, 2-6 June 2024. Guest Edited by Martha Vardaki and Nikos Kourkoumelis. New articles will be added to the collection as they are published.