Themed collection Journal of Materials Chemistry B Emerging Investigators 2025

Comprehensively acquiring biological tissue information is pivotal for advancing our understanding of biological systems, elucidating disease mechanisms, and developing innovative clinical strategies.

This review highlights the integration of bioorthogonal catalysis into macromolecular scaffolds to enable localized, in situ bond-forming reactions for prodrug activation, offering enhanced specificity and support for multimodal functionalities.

The advent of lipid nanoparticle (LNP) technology has marked a significant breakthrough in the field of drug delivery, offering unprecedented opportunities in gene therapy, vaccine delivery, and personalized medicine.

Metal organic frameworks with diverse photo-responsive antibacterial mechanisms for biomedical applications are summarized.

Eco-friendly carbon dots synthesized from Garcinia mangostana rind via solvothermal methods enhance PVC film photostability and mechanical properties, offering promising durability for sunlight-exposed applications such as food packaging.

Self-assembled nanoprodrug was constructed via coordinative interactions between artesunate-histidine conjugate and copper ions, serving as efficient Fenton-like reagent for robust ROS generation toward tumor therapy both in vitro and in vivo.

Herein, a new small molecule photosensitizer (DMATPE-MN) and photoinduced NO donor (NTA-CN) were designed to construct a nanotherapeutic platform for highly efficient photodynamic and NO synergistic therapy through the generation of peroxynitrite.

A green light-activated dual-release nanoplatform enabling NO and antibacterial polymer synergy for biofilm eradication with charge-switching enhancement is developed.

A feedback-regulated zeolitic imidazole framework-90 nanocomplex with high pulmonary accumulation and mitochondria-targeting capability is proposed for orthotopic tumor suppression via inhibition of the mitochondrial ATP synthetic pathway.

Zwitterionic based cyclic brush polymers provide improved lubrication and antioxidant properties.

A hollow Cu₂O@Au nanocube-based dual-model biosensor was developed for uric acid detection, combining colorimetry and laser desorption/ionization mass spectrometry.

Titanium dental implants are prone to infections by pathogenic bacteria, leading to the formation of biofilm and development of peri-implantitis.

To prevent PJI, PVA–TP–CA/Cu@TC4 was obtained by constructing a micro–nano structure on TC4 and loading a PVA gel coating, which exhibited enhanced biofunctional properties, including antibacterial, angiogenesis, and osteogenic activities.

A structural color hydrogel composed of a hybrid double-network is developed for accelerated wound healing and rehabilitation exercise monitoring.

An LPP binds to A-protein via electrostatic attraction and hydrogen bonding to form stable NCs. Upon endocytosis, the LPP induces rapid endolysosomal escape, and the native protein is restored by cleaving boronate ester and imine caging groups.

This paper provides first-time evidence of covalent attachment of fluorescent molecules to plasma polymerised nanoparticles for diagnostic and therapeutic applications.

This study investigates the impact of surface modifications on the protein corona formation around mesoporous silica nanoparticles, revealing how these modifications influence macrophage uptake.

Mosaic influenza antimicrobial peptide-like epitopes (Ampitopes) co-crystalize with poly(I:C), a TLR3 agonist, into nanocrystalline vaccine, which boosts immunogenicity via multivalent toll like receptor 3 (TLR3) binding and immune activation.

Gold nanorods-encapsulated liposomes enabled the on-demand release of melatonin in mouse glaucoma models.