Issue 58, 2014

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Abstract

The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Graphical abstract: Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Supplementary files

Article information

Article type
Communication
Submitted
19 apr 2014
Accepted
27 may 2014
First published
02 iyn 2014

Chem. Commun., 2014,50, 7824-7827

Author version available

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

M. Zan, J. Li, S. Luo and Z. Ge, Chem. Commun., 2014, 50, 7824 DOI: 10.1039/C4CC03120B

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