Issue 86, 2021

A rearrangement of saccharin-derived cyclic ketimines with 3-chlorooxindoles leading to spiro-1,3-benzothiazine oxindoles

Abstract

An unusual rearrangement of saccharin-derived cyclic ketimines (SDCIs) and 3-chlorooxindoles has been developed to provide a series of spiro-1,3-benzothiazine oxindoles. The reaction features simple manipulations, short reaction times, mild reaction conditions and inexpensive reagents. It is the first example where SDCIs serve as a ring-opening reagent in organic synthesis.

Graphical abstract: A rearrangement of saccharin-derived cyclic ketimines with 3-chlorooxindoles leading to spiro-1,3-benzothiazine oxindoles

Supplementary files

Article information

Article type
Communication
Submitted
01 avq 2021
Accepted
05 okt 2021
First published
05 okt 2021

Chem. Commun., 2021,57, 11322-11325

A rearrangement of saccharin-derived cyclic ketimines with 3-chlorooxindoles leading to spiro-1,3-benzothiazine oxindoles

R. Li, Q. Fang, M. Li, X. Wang and L. Zhao, Chem. Commun., 2021, 57, 11322 DOI: 10.1039/D1CC04179G

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