Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees; C. Sewing; M. J. W. D. Vosjan; V. Tadino; J. D. M. Herscheid; A. D. Windhorst; D. J. Vugts

doi:10.1039/C8CC03206H

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Fast and reliable generation of [¹⁸F]triflyl fluoride, a gaseous [¹⁸F]fluoride source†

A. Pees,

*^a C. Sewing,^a M. J. W. D. Vosjan,^b V. Tadino,^c J. D. M. Herscheid,^a A. D. Windhorst

^a and D. J. Vugts

Author affiliations

* Corresponding authors

^a Department of Radiology & Nuclear Medicine, Location Radionuclidecenter, De Boelelaan 1085C, 1081 HV Amsterdam, The Netherlands
E-mail: a.pees@vumc.nl

^b BV Cyclotron VU, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

^c ORA Neptis, Rue de la Gendarmerie 50/B, 5600 Philippeville, Belgium

Abstract

A novel strategy for the production of reactive [¹⁸F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [¹⁸F]triflyl fluoride is formed instantaneously at room temperature from hydrated [¹⁸F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [¹⁸F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [¹⁸F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [¹⁸F]fluoroestradiol ([¹⁸F]FES) and O-2-[¹⁸F]fluoroethyl-L-tyrosine ([¹⁸F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol⁻¹.

This article is part of the themed collection: Fluorine Chemistry

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Article information

DOI: https://doi.org/10.1039/C8CC03206H
Article type: Communication
Submitted: 20 Apr 2018
Accepted: 01 Jun 2018
First published: 23 Aug 2018
This article is Open Access

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Chem. Commun., 2018,54, 10179-10182

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Fast and reliable generation of [¹⁸F]triflyl fluoride, a gaseous [¹⁸F]fluoride source

A. Pees, C. Sewing, M. J. W. D. Vosjan, V. Tadino, J. D. M. Herscheid, A. D. Windhorst and D. J. Vugts, Chem. Commun., 2018, 54, 10179 DOI: 10.1039/C8CC03206H

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