Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect

Dingze Mang; Shijin Zhang; Xia Wu; Xunwu Hu; Toshiaki Mochizuki; Guanying Li; Ye Zhang

doi:10.1039/C9CC02715G

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Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect†

Dingze Mang,‡^a Shijin Zhang,^a Xia Wu,^a Xunwu Hu,^a Toshiaki Mochizuki,^b Guanying Li^a and Ye Zhang

*^a

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* Corresponding authors

^a Bioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, Japan
E-mail: ye.zhang@oist.jp

^b Imaging Section, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, Japan

Abstract

We designed and synthesized homochiral-peptide-based boron diketonate complexes. Co-administration of the two stereoisomers in cancer cells led to molecular assembly targeting both the plasma membrane and the lysosomes mediated via membrane-bonded enzymes. The dual-targeted-assembly generates a synergistic anticancer effect with amplified cancer spheroid toxicity and enhanced inhibition efficacy on cancer cell migration.

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DOI: https://doi.org/10.1039/C9CC02715G
Article type: Communication
Submitted: 08 Apr 2019
Accepted: 01 May 2019
First published: 09 May 2019

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Chem. Commun., 2019,55, 6126-6129

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Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect

D. Mang, S. Zhang, X. Wu, X. Hu, T. Mochizuki, G. Li and Y. Zhang, Chem. Commun., 2019, 55, 6126 DOI: 10.1039/C9CC02715G

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Chemical Communications

Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect†

Abstract

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Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect

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