CuCo2S4 nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation

Xing Zhang; Junchao Liu; Xinrui Yang; Guanjie He; Bo Li; Jinbao Qin; Paul R. Shearing; Dan J. L. Brett; Junqing Hu; Xinwu Lu

doi:10.1039/C9NR00772E

CuCo₂S₄ nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation†

Xing Zhang,‡^a Junchao Liu,‡^a Xinrui Yang,‡^a Guanjie He,

^b Bo Li,

*^a Jinbao Qin,*^a Paul R. Shearing,

^b Dan J. L. Brett,

^b Junqing Hu

*^acd and Xinwu Lu*^a

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* Corresponding authors

^a Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
E-mail: boli@shsmu.edu.cn, jinbaoqin@163.com, luxinwu@shsmu.edu.cn

^b Electrochemical Innovation Lab, Department of Chemical Engineering, University College London, London WC1E 7JE, UK

^c College of Materials Science and Engineering, Donghua University, Shanghai, China

^d College of Health Science and Environmental Engineering, Shenzhen Technology University, 3002 Lantian Road, Pingshan District, Shenzhen 518118, China
E-mail: hu.junqing@dhu.edu.cn

Abstract

Ultrasmall CuCo₂S₄ nanocrystals (NCs) have been demonstrated as an effective agent in the photothermal therapy (PTT) of tumors, but have not been investigated for treatment of arterial inflammation, which is critical in the initiation and development of atherosclerosis (AS), a leading cause of vascular diseases worldwide. In this study, CuCo₂S₄ NCs were synthesized and used as an efficient PTT nanoplatform for arterial inflammation. In vitro experiments illustrated an effective ablation of inflammatory macrophages by CuCo₂S₄ incubation combined with the irradiation with an 808 nm near-infrared (NIR) laser. In vivo experiments in an apolipoprotein E knockout (Apo E−/−) mouse model showed that the local injection with CuCo₂S₄ followed by irradiation with an 808 nm NIR laser notably ablated infiltrating inflammatory macrophages and effectively reduced arterial inflammation and arterial stenosis. This work provides a new strategy for treatment of AS by exploring bimetal sulfides as effective PTT agents.

Nanoscale

CuCo₂S₄ nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation†

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CuCo₂S₄ nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation

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