Issue 30, 2024
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RSC Advances

A ternary system of meloxicam with matching hydrophilic polymer and cyclodextrin for improved stability in liquid preprations

Si Li,a   Longfa Kou,ac   Yimeng Qin,a   Yimeng Wang,b   Yinghua Sun, ORCID logo *b   Zhonggui Heb  and  Xiaohong Liu*a  

* Corresponding authors

a School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China

b Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
E-mail: sunyinghua77@aliyun.com
Fax: +86-24-23986321
Tel: +86-24-23986321

c Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325035, China

Abstract

The purpose of the study is to investigate the effect of ternary systems consisting of meloxicam with cyclodextrins (HP-β-CD or SBE-β-CD) and different polymers (HA, HPMC and PVP) on the stability of meloxicam. The t0.9 values of meloxicam were determined within all the aforementioned systems and the influence of various polymers on the alteration in meloxicam's stability was evaluated. All three polymers altered the stability of meloxicam to varying degrees, with the extent of the effect being related to hydrophilicity, concentration of components, and the interaction of the newly formed ternary system. Among them, meloxicam demonstrated its highest degree of stabilization within the ternary system formed by SBE-β-CD&HPMC and HP-β-CD&HA. We characterized the ternary system of meloxicam using differential scanning calorimetry (DSC), X-ray diffraction, and scanning electron microscopy analysis, which determined the presence of ternary system inclusions. In addition, we investigated the optimized prescription of eye drops of meloxicam using the ternary system and further determined that the ternary system improved the stability of the drug in liquid formulations.

Graphical abstract: A ternary system of meloxicam with matching hydrophilic polymer and cyclodextrin for improved stability in liquid preprations

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Article information

DOI
https://doi.org/10.1039/D4RA02811B
Article type
Paper
Submitted
16 Apr 2024
Accepted
29 Jun 2024
First published
05 Jul 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 21260-21268

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A ternary system of meloxicam with matching hydrophilic polymer and cyclodextrin for improved stability in liquid preprations

S. Li, L. Kou, Y. Qin, Y. Wang, Y. Sun, Z. He and X. Liu, RSC Adv., 2024, 14, 21260 DOI: 10.1039/D4RA02811B

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