Total synthesis of clavulanic acid analogues from 7-oxo-3-vinyl-4-oxa-1-azabicyclo[3.2.0]heptanes
Abstract
A 3-vinyl group has been incorporated into the 7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane ring system by way of the selenoxide elimination process, or by utilising a novel 3-vinylserine derivative, and its transformation to an alkoxyethylidene group demonstrated.