Issue 11, 1994
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis and biological activity of the diphosphorylphosphonate derivatives of (+)- and (–)-cis-9-(4′-hydroxycyclopent-2′-enyl)guanine

Valeria Merlo,   Stanley M. Roberts,   Richard Storer  and  Richard C. Bethell  

Abstract

The carbovir triphosphate analogue 10 and its enantiomer 11 have been synthesized and tested as inhibitors of HIV-reverse transcriptase; the enantiomer 11, more remotely resembling natural nucleotides in stereochemical terms, is surprisingly the more active compound.

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Article information

DOI
https://doi.org/10.1039/P19940001477
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1994, 1477-1481

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Synthesis and biological activity of the diphosphorylphosphonate derivatives of (+)- and (–)-cis-9-(4′-hydroxycyclopent-2′-enyl)guanine

V. Merlo, S. M. Roberts, R. Storer and R. C. Bethell, J. Chem. Soc., Perkin Trans. 1, 1994, 1477 DOI: 10.1039/P19940001477

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