Solid phase lipid synthesis (SPLS) for construction of an artificial glycolipid libraryDetails of the release of Glc-asp(NH2)-2C12 from resin 5 and the synthesis of Glc-asp(CO2H)-2C12 are available as electronic supplementary information (ESI). See http://www.rsc.org/suppdata/cc/b0/b002545n/

Abstract

A simple solid phase lipid synthesis (SPLS) is proposed for construction of an artificial glycolipid library; this method is so convenient and flexible that we have efficiently constructed a glycolipid library; some of these glycolipids formed into stable bilayer aggregates in aqueous solution, suggesting that the glycolipids obtained by SPLS are useful as a suitable model of naturally occurring glycolipids.