Issue 2, 2001
From the journal:

Chemical Communications

Epoxyalcohol route to hydroxyethylenedipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

Fabio Benedetti*a  and  Stefano Norbedoa  

* Corresponding authors

a Department of Chemical Sciences, University of Trieste, Via Giorgieri 1, Trieste, Italy.
E-mail: benedett@univ.trieste.it
Fax: Fax: +39 040 6763903;
Tel: Phone: +39 040 6763919

Abstract

A stereoselective synthesis of the diaminoalcohol core of Ritonavir illustrates a novel approach to hydroxyethylene dipeptide isosteres, based on the regioselective reduction of amino acid-derived epoxyalcohols.

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Article information

DOI
https://doi.org/10.1039/B005804L
Article type
Communication
Submitted
13 Jul 2000
Accepted
08 Dec 2000
First published
09 Jan 2001

Chem. Commun., 2001, 203-204

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Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

F. Benedetti and S. Norbedo, Chem. Commun., 2001, 203 DOI: 10.1039/B005804L

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