Issue 2, 2003
From the journal:

Chemical Communications

Studies towards the total synthesis of an epoxy isoprostane phospholipid, a potent activator of endothelial cells

Michael E. Jung,*a   Annika Kers,a   Ganesamoorthy Subbanagounderb  and  Judith A. Berlinerb  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA, USA
E-mail: jung@chem.ucla.edu
Fax: 310 206-3722
Tel: 310 825-7954

b Department of Medicine, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA, USA
E-mail: jberliner@mednet.ucla.edu
Fax: 310 267-2163
Tel: 310 825-2436

Abstract

We report studies toward the total synthesis of an epoxy isoprostane, namely the preparation of compound 9 which is an analogue of the elimination product 7 of the naturally occurring epoxy isoprostane 4 by a straightforward route using a three-component coupling, and have shown by several spectroscopic criteria that it closely resembles the natural material.

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Article information

DOI
https://doi.org/10.1039/B209892J
Article type
Communication
Submitted
14 Oct 2002
Accepted
14 Nov 2002
First published
17 Dec 2002

Chem. Commun., 2003, 196-197

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Studies towards the total synthesis of an epoxy isoprostane phospholipid, a potent activator of endothelial cells

M. E. Jung, A. Kers, G. Subbanagounder and J. A. Berliner, Chem. Commun., 2003, 196 DOI: 10.1039/B209892J

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