Issue 8, 2003
From the journal:

Chemical Communications

A novel peptide synthesis using fluorous chemistry

Mamoru Mizuno,a   Kohtaro Goto,a   Tsuyoshi Miura,a   Daisuke Hosakaa  and  Toshiyuki Inazu*a  

* Corresponding authors

a The Noguchi Institute, 1-8-1, Kaga, Tokyo 173-0003, Japan
E-mail: inz@noguchi.or.jp

Abstract

Three new fluorous supports for peptide synthesis, i.e., the trialkoxybenzhydryl-type (6), the Wang-type (7) and the tert-butyl-type support (8), were prepared. A bioactive peptide TRH was easily synthesized by an Fmoc strategy using the benzhydryl-type fluorous support with fluorous chemistry.

Graphical abstract: A novel peptide synthesis using fluorous chemistry

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Article information

DOI
https://doi.org/10.1039/B300682D
Article type
Communication
Submitted
30 Jan 2003
Accepted
03 Mar 2003
First published
18 Mar 2003

Chem. Commun., 2003, 972-973

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A novel peptide synthesis using fluorous chemistry

M. Mizuno, K. Goto, T. Miura, D. Hosaka and T. Inazu, Chem. Commun., 2003, 972 DOI: 10.1039/B300682D

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