Issue 23, 2005
From the journal:

Chemical Communications

The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

Steen Saaby,a   Kristian Rahbek Knudsen,a   Mark Ladlowb  and  Steven V. Ley*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: 44 (0) 1223 336442
Tel: 44 (0) 1223 336398

b GlaxoSmithKline Cambridge Technology Centre, University of Cambridge, Cambridge, UK

Abstract

Imines have been reduced to amines in high yield, and with excellent chemoselectivity, by catalytic hydrogenation in a continuous flow-reactor, utilising an electrochemically-generated hydrogen source to produce a mixed hydrogen–liquid flow stream.

Graphical abstract: The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

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Article information

DOI
https://doi.org/10.1039/B504854K
Article type
Communication
Submitted
07 Apr 2005
Accepted
21 Apr 2005
First published
17 May 2005

Chem. Commun., 2005, 2909-2911

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The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

S. Saaby, K. R. Knudsen, M. Ladlow and S. V. Ley, Chem. Commun., 2005, 2909 DOI: 10.1039/B504854K

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