Issue 38, 2005
From the journal:

Chemical Communications

Chemical optimization of artificial metalloenzymes based on the biotin-avidin technology: (S)-selective and solvent-tolerant hydrogenation catalystsvia the introduction of chiral amino acid spacers†

Myriem Skander,a   Christophe Malan,a   Anita Ivanovaa  and  Thomas R. Ward*a  

* Corresponding authors

a Institute of Chemistry, University of Neuchâtel, Av. de Bellevaux 51, CP2, CH-2007, Neuchâtel, Switzerland
E-mail: thomas.ward@unine.ch
Fax: +41 32 718 25 11
Tel: +41 32 718 25 16

Abstract

Incorporation of biotinylated-[rhodium(diphosphine)]+ complexes, with enantiopure amino acid spacers, in streptavidin affords solvent-tolerant and selective artificial metalloenzymes: up to 91% ee (S) in the hydrogenation of N-protected dehydroamino acids.

Graphical abstract: Chemical optimization of artificial metalloenzymes based on the biotin-avidin technology: (S)-selective and solvent-tolerant hydrogenation catalysts via the introduction of chiral amino acid spacers

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B509015F
Article type
Communication
Submitted
27 Jun 2005
Accepted
05 Aug 2005
First published
01 Sep 2005

Chem. Commun., 2005, 4815-4817

Permissions

Request permissions

Chemical optimization of artificial metalloenzymes based on the biotin-avidin technology: (S)-selective and solvent-tolerant hydrogenation catalysts via the introduction of chiral amino acid spacers

M. Skander, C. Malan, A. Ivanova and T. R. Ward, Chem. Commun., 2005, 4815 DOI: 10.1039/B509015F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements