Issue 38, 2005
From the journal:

Chemical Communications

Recognition of guanines at a double helix–coil junction in DNA by a trinuclear copper complex†

Takeo Ito,ab   Sunita Thyagarajan,c   Kenneth D. Karlinc  and  Steven E. Rokita*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Maryland, College Park, USA
E-mail: rokita@umd.edu
Fax: +1 301-405-9376
Tel: +1 301-405-1816

b Current Address: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan

c Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, USA

Abstract

Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix–coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.

Graphical abstract: Recognition of guanines at a double helix–coil junction in DNA by a trinuclear copper complex

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Article information

DOI
https://doi.org/10.1039/B509690A
Article type
Communication
Submitted
08 Jul 2005
Accepted
05 Aug 2005
First published
31 Aug 2005

Chem. Commun., 2005, 4812-4814

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Recognition of guanines at a double helix–coil junction in DNA by a trinuclear copper complex

T. Ito, S. Thyagarajan, K. D. Karlin and S. E. Rokita, Chem. Commun., 2005, 4812 DOI: 10.1039/B509690A

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