Issue 7, 2006
From the journal:

Chemical Communications

Activity-based high-throughput profiling of metalloprotease inhibitors using small molecule microarrays†

Jun Wang,a   Mahesh Uttamchandani,b   Li Ping Suna  and  Shao Q. Yao*abc  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: (+65) 67791691
Tel: (+65) 68741683

b Department of Biological Sciences, National University of Singapore, Singapore

c NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore

Abstract

We herein describe a high-throughput small molecule microarray (SMM) method that enables quick and cost-effective identification of potent inhibitors of metalloproteases in an activity-dependent manner, thereby offering a rapid means for inhibitor discovery and profiling.

Graphical abstract: Activity-based high-throughput profiling of metalloprotease inhibitors using small molecule microarrays

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Article information

DOI
https://doi.org/10.1039/B515278J
Article type
Communication
Submitted
27 Oct 2005
Accepted
01 Dec 2005
First published
04 Jan 2006

Chem. Commun., 2006, 717-719

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Activity-based high-throughput profiling of metalloprotease inhibitors using small molecule microarrays

J. Wang, M. Uttamchandani, L. P. Sun and S. Q. Yao, Chem. Commun., 2006, 717 DOI: 10.1039/B515278J

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