Issue 2, 2008
From the journal:

Chemical Communications

Biodegradable microcapsules designed via ‘click’ chemistry†

Bruno G. De Geest,*ab   Wim Van Camp,‡c   Filip E. Du Prez,c   Stefaan C. De Smedt,b   Jo Demeesterb  and  Wim E. Henninka  

* Corresponding authors

a Department of Pharmaceutics, Utrecht University, 3584 CA Utrecht, The Netherlands
E-mail: br.degeest@ugent.be
Fax: +32 9 2648189
Tel: +32 9 264 80 74

b Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, 9000 Ghent, Belgium

c Polymer Chemistry Research Group, Department of Organic Chemistry, Ghent University, 9000 Ghent, Belgium

Abstract

Dextrans modified with alkyne and azide groups through hydrolysable carbonate esters form degradable microcapsules after CuI catalysed ‘click’ reaction between azides and alkynes yielding triazolecross-links.

Graphical abstract: Biodegradable microcapsules designed via ‘click’ chemistry

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Article information

DOI
https://doi.org/10.1039/B714199H
Article type
Communication
Submitted
13 Sep 2007
Accepted
07 Nov 2007
First published
14 Nov 2007

Chem. Commun., 2008, 190-192

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Biodegradable microcapsules designed via ‘click’ chemistry

B. G. De Geest, W. Van Camp, F. E. Du Prez, S. C. De Smedt, J. Demeester and W. E. Hennink, Chem. Commun., 2008, 190 DOI: 10.1039/B714199H

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