Fluorescent probe: complexation of Fe3+with the myo-inositol 1,2,3-trisphosphate motif

David Mansell; Nicholas Rattray; Laura L. Etchells; Carl H. Schwalbe; Alexander J. Blake; Elena V. Bichenkova; Richard A. Bryce; Christopher J. Barker; Alvaro Díaz; Carlos Kremer; Sally Freeman

doi:10.1039/B809238A

Fluorescent probe: complexation of Fe³⁺with the myo-inositol 1,2,3-trisphosphate motif†

David Mansell,^a Nicholas Rattray,^a Laura L. Etchells,^a Carl H. Schwalbe,^b Alexander J. Blake,^c Elena V. Bichenkova,^a Richard A. Bryce,^a Christopher J. Barker,^d Alvaro Díaz,^e Carlos Kremer^f and Sally Freeman*^a

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^a School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, UK
E-mail: sally.freeman@manchester.ac.uk
Fax: 44 161 275 2396
Tel: 44 161 275 2366

^b School of Life and Health Sciences, Aston University, Birmingham, UK

^c School of Chemistry, The University of Nottingham, University Park, Nottingham, UK

^d Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden

^e Cátedra de Inmunología, Facultad de Química/Ciencias, Universidad de la República, Avenida Alfredo Navarro 3051, Montevideo, Uruguay

^f Cátedra de Química Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo, Uruguay

Abstract

Natural myo-inositol phosphate antioxidants containing the 1,2,3-trisphosphate motif bind Fe³⁺ in the unstable penta-axial conformation.

Chemical Communications

Fluorescent probe: complexation of Fe³⁺with the myo-inositol 1,2,3-trisphosphate motif†

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Fluorescent probe: complexation of Fe³⁺with the myo-inositol 1,2,3-trisphosphate motif

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