Issue 23, 2009
From the journal:

Chemical Communications

A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl)phenyl esters†

Masahito Murai,a   Koji Mikia  and  Kouichi Ohe*a  

* Corresponding authors

a Department of Energy Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan
E-mail: ohe@scl.kyoto-u.ac.jp
Fax: +81 75-383-2499
Tel: +81 75-383-2495

Abstract

Treatment of 2-(cyanomethyl)phenyl esters with a catalytic amount of Pd(OAc)2, PCy3, and Zn afforded 3-acyl-2-aminobenzofuran derivatives in good to excellent yields, which can be used as building blocks for the synthesis of benzofuran fused heterocycles.

Graphical abstract: A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl)phenyl esters

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Article information

DOI
https://doi.org/10.1039/B904127C
Article type
Communication
Submitted
27 Feb 2009
Accepted
07 Apr 2009
First published
07 May 2009

Chem. Commun., 2009, 3466-3468

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A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl)phenyl esters

M. Murai, K. Miki and K. Ohe, Chem. Commun., 2009, 3466 DOI: 10.1039/B904127C

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