Issue 42, 2009
From the journal:

Chemical Communications

MRI contrast agent delivery using spore capsules: controlled release in blood plasma†

Mark Lorch,a   Matthew J. Thomasson,a   Alberto Diego-Taboada,a   Sylvain Barrier,a   Stephen L. Atkin,b   Grahame Mackenziea  and  Stephen J. Archibald*a  

* Corresponding authors

a Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK
E-mail: s.j.archibald@hull.ac.uk
Fax: +44 (0)1482 466410
Tel: +44 (0)1482 465488

b Department of Endocrinology and Diabetes, University of Hull, Cottingham Road, Hull, UK

Abstract

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd–DTPA–BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

Graphical abstract: MRI contrast agent delivery using spore capsules: controlled release in blood plasma

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Article information

DOI
https://doi.org/10.1039/B909551A
Article type
Communication
Submitted
13 May 2009
Accepted
08 Sep 2009
First published
01 Oct 2009

Chem. Commun., 2009, 6442-6444

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MRI contrast agent delivery using spore capsules: controlled release in blood plasma

M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie and S. J. Archibald, Chem. Commun., 2009, 6442 DOI: 10.1039/B909551A

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