Issue 6, 2009
From the journal:

Organic & Biomolecular Chemistry

Fluoride-free cross coupling using vinyldisiloxanes†

Hannah F. Sore,a   Christine M. Boehner,a   Simon J. F. MacDonald,b   David Norton,c   David J. Foxd  and  David R. Spring*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

c GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, UK

d Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, UK

Abstract

Vinyldisiloxanes equilibrate with the corresponding silanolates under basic conditions and subsequently undergo palladium catalysed cross coupling with aryl/heteroaryl iodides and bromides.

Graphical abstract: Fluoride-free cross coupling using vinyldisiloxanes

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Article information

DOI
https://doi.org/10.1039/B900852G
Article type
Communication
Submitted
14 Jan 2009
Accepted
16 Jan 2009
First published
23 Jan 2009

Org. Biomol. Chem., 2009,7, 1068-1072

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Fluoride-free cross coupling using vinyldisiloxanes

H. F. Sore, C. M. Boehner, S. J. F. MacDonald, D. Norton, D. J. Fox and D. R. Spring, Org. Biomol. Chem., 2009, 7, 1068 DOI: 10.1039/B900852G

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