Issue 3, 2010
From the journal:

Chemical Communications

A pH-driven DNA switch based on the A+·G mispair†

Jennifer A. Leea  and  Maria C. DeRosa*a  

* Corresponding authors

a Chemistry Department, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
E-mail: maria_derosa@carleton.ca
Fax: (613) 520-3749
Tel: (613) 520-2600 ext. 3844

Abstract

A new approach to the development of pH-driven DNA switches is presented. Here, the improved stability of the A·G mispair under slightly acidic conditions is exploited. The temperature tunability and the potential generality of the approach are discussed.

Graphical abstract: A pH-driven DNA switch based on the A+·G mispair

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Article information

DOI
https://doi.org/10.1039/B918725A
Article type
Communication
Submitted
09 Sep 2009
Accepted
05 Nov 2009
First published
25 Nov 2009

Chem. Commun., 2010,46, 418-420

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A pH-driven DNA switch based on the A+·G mispair

J. A. Lee and M. C. DeRosa, Chem. Commun., 2010, 46, 418 DOI: 10.1039/B918725A

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