Issue 25, 2010
From the journal:

Chemical Communications

Biodegradable and pH-sensitive polymersome with tuning permeable membrane for drug delivery carrier†

Min Sang Kima  and  Doo Sung Lee*a  

* Corresponding authors

a Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Korea
E-mail: dslee@skku.edu
Fax: +82 31 292 8790
Tel: +82 31 290 7267

Abstract

Novel biodegradable and pH-sensitive polymersomes prepared from poly(ethylene glycol) and poly(D,L-lactide) grafted poly(β-amino ester) exhibit pH dependent permeability on hydrophilic solutes of which permeability is determined by the packing state of poly(D,L-lactide) membrane followed by ionization of poly(β-amino ester) inducing loosely packed membrane formation from well-ordered packing.

Graphical abstract: Biodegradable and pH-sensitive polymersome with tuning permeable membrane for drug delivery carrier

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Article information

DOI
https://doi.org/10.1039/C001500H
Article type
Communication
Submitted
22 Jan 2010
Accepted
28 Apr 2010
First published
12 May 2010

Chem. Commun., 2010,46, 4481-4483

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Biodegradable and pH-sensitive polymersome with tuning permeable membrane for drug delivery carrier

M. S. Kim and D. S. Lee, Chem. Commun., 2010, 46, 4481 DOI: 10.1039/C001500H

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