Issue 30, 2010
From the journal:

Chemical Communications

Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection†

Sai Bi,a   Jilei Zhanga  and  Shusheng Zhang*a  

* Corresponding authors

a Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
E-mail: shushzhang@126.com
Fax: 86 532 84022750
Tel: 86 532 84022750

Abstract

By significantly circumventing the typical problem of high background induced by excess hemin itself, an ultrasensitive DNA amplified detection method is developed based on nicking endonuclease (NEase) assisted strand scission cycle, which is further successfully applied in cancer cell detection.

Graphical abstract: Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

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Article information

DOI
https://doi.org/10.1039/C0CC00127A
Article type
Communication
Submitted
26 Feb 2010
Accepted
01 Apr 2010
First published
29 Apr 2010

Chem. Commun., 2010,46, 5509-5511

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Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

S. Bi, J. Zhang and S. Zhang, Chem. Commun., 2010, 46, 5509 DOI: 10.1039/C0CC00127A

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