Issue 26, 2010
From the journal:

Chemical Communications

A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP†

Ben Newland,a   Hongyun Tai,b   Yu Zheng,c   Diego Velasco,a   Andrea Di Luca,a   Steven M. Howdle,c   Cameron Alexander,d   Wenxin Wang*a  and  Abhay Pandit*a  

* Corresponding authors

a Network of Excellence for Functional Biomaterials, National University of Ireland Galway, Galway, Ireland
E-mail: wenxin.wang@nuigalway.ie, abhay.pandit@nuigalway.ie
Fax: +353 (0)91 49 5585
Tel: +353 91 49 2758

b School of Chemistry, Bangor University, Deiniol Road, Bangor, Gwynedd, UK

c School of Chemistry, University of Nottingham, University Park, Nottingham, UK

d School of Pharmacy, University of Nottingham, University Park, Nottingham, UK

Abstract

A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect® dendrimer but with lower cytotoxicity.

Graphical abstract: A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

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Article information

DOI
https://doi.org/10.1039/C0CC00439A
Article type
Communication
Submitted
17 Mar 2010
Accepted
14 May 2010
First published
01 Jun 2010

Chem. Commun., 2010,46, 4698-4700

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A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

B. Newland, H. Tai, Y. Zheng, D. Velasco, A. Di Luca, S. M. Howdle, C. Alexander, W. Wang and A. Pandit, Chem. Commun., 2010, 46, 4698 DOI: 10.1039/C0CC00439A

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