Issue 42, 2010
From the journal:

Chemical Communications

Biomimetic glass nanopores employing aptamer gates responsive to a small molecule†

Alexis E. Abelow,a   Olga Schepelina,a   Ryan J. White,b   Alexis Vallée-Bélisle,b   Kevin W. Plaxco*b  and  Ilya Zharov*a  

* Corresponding authors

a Department of Chemistry, University of Utah, 315 S. 1400 E. Salt Lake City, USA
E-mail: i.zharov@utah.edu
Fax: +1 801-581-8433
Tel: +1 801-587-9335

b Department of Chemistry and Biochemistry, and Program in Biomolecular Science and Engineering, University of California, Santa Barbara, USA
E-mail: kwp@chem.ucsb.edu

Abstract

We report the preparation of 20 and 65 nm radii glass nanopores whose surface is modified with DNA aptamers controlling the molecular transport through the nanopores in response to small molecule binding.

Graphical abstract: Biomimetic glass nanopores employing aptamer gates responsive to a small molecule

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Article information

DOI
https://doi.org/10.1039/C0CC02649B
Article type
Communication
Submitted
19 Jul 2010
Accepted
24 Aug 2010
First published
23 Sep 2010

Chem. Commun., 2010,46, 7984-7986

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Biomimetic glass nanopores employing aptamer gates responsive to a small molecule

A. E. Abelow, O. Schepelina, R. J. White, A. Vallée-Bélisle, K. W. Plaxco and I. Zharov, Chem. Commun., 2010, 46, 7984 DOI: 10.1039/C0CC02649B

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