Issue 5, 2011
From the journal:

Chemical Communications

Synthesis of 6-trifluoromethylindolo[1,2-c]quinazolines and related heterocycles using N-(2-iodophenyl)trifluoroacetimidoyl chlorides as starting material via C–H bond functionalization†

Jiangtao Zhu,a   Haibo Xie,a   Zixian Chen,ab   Shan Lia  and  Yongming Wu*a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling, Road, Shanghai 200032, China
E-mail: ymwu@mail.sioc.ac.cn
Fax: +86 21-64166128

b Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China

Abstract

A mild, two-step reaction for the synthesis of 6-trifluoromethylindolo[1,2-c]quinazolines from readily available indoles and N-(2-iodophenyl)trifluoroacetimidoyl chlorides via addition–elimination/arylation is described. An array of aza-fused trifluoromethylated heterocycles can be easily assembled via Friedel–Crafts reaction/C–H bond activation by this methodology.

Graphical abstract: Synthesis of 6-trifluoromethylindolo[1,2-c]quinazolines and related heterocycles using N-(2-iodophenyl)trifluoroacetimidoyl chlorides as starting material via C–H bond functionalization

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Article information

DOI
https://doi.org/10.1039/C0CC03197F
Article type
Communication
Submitted
12 Aug 2010
Accepted
28 Oct 2010
First published
22 Nov 2010

Chem. Commun., 2011,47, 1512-1514

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Synthesis of 6-trifluoromethylindolo[1,2-c]quinazolines and related heterocycles using N-(2-iodophenyl)trifluoroacetimidoyl chlorides as starting material via C–H bond functionalization

J. Zhu, H. Xie, Z. Chen, S. Li and Y. Wu, Chem. Commun., 2011, 47, 1512 DOI: 10.1039/C0CC03197F

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