Issue 2, 2011
From the journal:

Chemical Communications

Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery†

Kyle E. Broaders,a   Stefan J. Pastine,a   Sirisha Grandhea  and  Jean M. J. Fréchet*ab  

* Corresponding authors

a Department of Chemistry, UC Berkeley, Berkeley, CA, USA
E-mail: fretchet@cchem.berkeley.edu

b Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA

Abstract

Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

Graphical abstract: Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

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Article information

DOI
https://doi.org/10.1039/C0CC04190D
Article type
Communication
Submitted
01 Oct 2010
Accepted
08 Nov 2010
First published
26 Nov 2010

Chem. Commun., 2011,47, 665-667

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Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

K. E. Broaders, S. J. Pastine, S. Grandhe and J. M. J. Fréchet, Chem. Commun., 2011, 47, 665 DOI: 10.1039/C0CC04190D

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