Issue 2, 2011
From the journal:

Chemical Communications

A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis†

Martyn Inmana  and  Christopher J. Moody*a  

* Corresponding authors

a School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: c.j.moody@nottingham.ac.uk
Fax: +44 115 951 3564

Abstract

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

Graphical abstract: A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

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Article information

DOI
https://doi.org/10.1039/C0CC04306K
Article type
Communication
Submitted
08 Oct 2010
Accepted
01 Nov 2010
First published
22 Nov 2010

Chem. Commun., 2011,47, 788-790

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A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

M. Inman and C. J. Moody, Chem. Commun., 2011, 47, 788 DOI: 10.1039/C0CC04306K

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