Issue 17, 2011
From the journal:

Chemical Communications

DOTASQ as a prototype of nature-inspired G-quadruplex ligand†

Loic Stefan,a   Aurore Guédin,b   Samir Amrane,b   Nicole Smith,b   Franck Denat,a   Jean-Louis Mergnyb  and  David Monchaud*a  

* Corresponding authors

a Institut de Chimie Moléculaire, CNRS UMR5260, Université de Bourgogne, Dijon, France
E-mail: david.monchaud@u-bourgogne.fr
Fax: +33 380 396 098
Tel: +33 380 399 043

b INSERM U869, Institut Européen de Chimie et Biologie, Université de Bordeaux, Pessac, France

Abstract

DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).

Graphical abstract: DOTASQ as a prototype of nature-inspired G-quadruplex ligand

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Article information

DOI
https://doi.org/10.1039/C0CC04960C
Article type
Communication
Submitted
15 Nov 2010
Accepted
01 Mar 2011
First published
22 Mar 2011

Chem. Commun., 2011,47, 4992-4994

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DOTASQ as a prototype of nature-inspired G-quadruplex ligand

L. Stefan, A. Guédin, S. Amrane, N. Smith, F. Denat, J. Mergny and D. Monchaud, Chem. Commun., 2011, 47, 4992 DOI: 10.1039/C0CC04960C

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