Issue 15, 2011
From the journal:

Chemical Communications

Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill†

Rico Thorwirth,a   Achim Stolle,*a   Bernd Ondruschka,a   Andreas Wildb  and  Ulrich S. Schubertb  

* Corresponding authors

a Institute for Technical Chemistry and Environmental Chemistry (ITUC), Friedrich-Schiller University Jena, Lessingstr. 12, D-07743 Jena, Germany
E-mail: achim.stolle@uni-jena.de
Fax: +49 3641 948402

b Laboratory for Organic and Macromolecular Chemistry (IOMC) and Jena Center for Soft Matter (JCSM), Friedrich-Schiller University Jena, Humboldtstr. 10, D-07743 Jena, Germany

Abstract

A new, ligand- and solvent-free method for the Huisgen 1,3-dipolar cycloaddition (click reaction) was developed using a planetary ball mill. Besides various alkynes and azides, a propargyl functionalized polymer was converted by mill clicking. Moreover, it was possible to carry out a clickpolymerization in a ball mill.

Graphical abstract: Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill

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Article information

DOI
https://doi.org/10.1039/C0CC05657J
Article type
Communication
Submitted
18 Dec 2010
Accepted
23 Feb 2011
First published
11 Mar 2011

Chem. Commun., 2011,47, 4370-4372

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Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill

R. Thorwirth, A. Stolle, B. Ondruschka, A. Wild and U. S. Schubert, Chem. Commun., 2011, 47, 4370 DOI: 10.1039/C0CC05657J

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