Issue 29, 2011
From the journal:

Chemical Communications

A water-soluble perylenedye functionalised with a 17β-estradiol: a new fluorescent tool for steroid hormones†‡

Francisco J. Céspedes-Guirao,a   Ana B. Ropero,b   Enrique Font-Sanchis,a   Ángel Nadal,*b   Fernando Fernández-Lázaro*a  and  Ángela Sastre-Santos*a  

* Corresponding authors

a División de Química Orgánica, Instituto de Bioingeniería, Universidad Miguel Hernández, Elche 03202, Spain
E-mail: asastre@umh.es, fdofdez@umh.es

b Unidad de Fisiología Celular y Nutrición, Instituto de Bioingeniería, Universidad Miguel Hernández, Elche 03202, Spain
E-mail: nadal@umh.es

Abstract

We have successfully been able to synthesise a specific estrogen receptor-directed biolabel based on a fluorescent water-soluble perylenebisimide, thus offering great potential for determining the presence of estrogen receptors in any kind of cell. Moreover, this synthetic strategy allows the preparation of other conjugates involved in the study of any kind of receptor, simply by selecting the appropriate agonist or antagonist.

Graphical abstract: A water-soluble perylene dye functionalised with a 17β-estradiol: a new fluorescent tool for steroid hormones

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Article information

DOI
https://doi.org/10.1039/C1CC10966A
Article type
Communication
Submitted
18 Feb 2011
Accepted
31 May 2011
First published
20 Jun 2011

Chem. Commun., 2011,47, 8307-8309

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A water-soluble perylene dye functionalised with a 17β-estradiol: a new fluorescent tool for steroid hormones

F. J. Céspedes-Guirao, A. B. Ropero, E. Font-Sanchis, Á. Nadal, F. Fernández-Lázaro and Á. Sastre-Santos, Chem. Commun., 2011, 47, 8307 DOI: 10.1039/C1CC10966A

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