Issue 29, 2011
From the journal:

Chemical Communications

Surface immobilizable chelator for label-free electrical detection of pyrophosphate†

David J. Liu,*a   Grace M. Credo,a   Xing Su,a   Kai Wu,a   Hsiao C. Lim,a   Oguz H. Elibol,ab   Rashid Bashirc  and  Madoo Varma*a  

* Corresponding authors

a Integrated Biosystems Lab, Intel Labs, Intel Corporation, 2200 Mission College Blvd., Santa Clara, USA
E-mail: djqliu@gmail.com, madoo.varma@intel.com
Fax: 408-765-2393
Tel: 408-653-9341

b Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA

c Departments of Electrical and Computer Engineering and Bioengineering, Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA

Abstract

A new pyrophosphate (PPi) chelator was designed for surface-sensitive electrical detection of biomolecular reactions. This article describes the synthesis of the PPi-selective receptor, its surface immobilization and application to label-free electrical detection on a silicon-based field-effect transistor (FET) sensor.

Graphical abstract: Surface immobilizable chelator for label-free electrical detection of pyrophosphate

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Article information

DOI
https://doi.org/10.1039/C1CC12073E
Article type
Communication
Submitted
12 Apr 2011
Accepted
01 Jun 2011
First published
20 Jun 2011

Chem. Commun., 2011,47, 8310-8312

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Surface immobilizable chelator for label-free electrical detection of pyrophosphate

D. J. Liu, G. M. Credo, X. Su, K. Wu, H. C. Lim, O. H. Elibol, R. Bashir and M. Varma, Chem. Commun., 2011, 47, 8310 DOI: 10.1039/C1CC12073E

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